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Bupropion hydrochloride extended-release tablets (SR) are not approved for use in pediatric patients. Although Bupropion is not metabolized by cytochrome P450IID6 (CYP2D6), there is the potential for drug-drug interactions when Bupropion is co-administered with drugs metabolized by this isoenzyme (see PRECAUTIONS: Drug Interactions). They were randomly assigned to pharmacotherapy (nicotine patch or bupropion), pharmacotherapy supplemented with up to two calls from trained counselors, or pharmacotherapy and up to six counseling calls. However, it has been demonstrated in an antidepressant screening test in mice that hydroxyBupropion is one half as potent as Bupropion, while threohydroBupropion and erythrohydroBupropion are 5-fold less potent than Bupropion.   While the mechanism of action of Bupropion, as with other antidepressants, is unknown, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms.

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